0613 Actigraphy-Based Sleep Disruption and Diurnal Biomarkers of Autonomic Function in Paroxysmal Atrial Fibrillation

Abstract Introduction Sleep architectural disruption is associated with atrial fibrillation (AF), however, autonomic influences remain unclear and it unknown if this detriment persists during wakefulness. We hypothesize diurnal-patterned associations of sleep dysfunction in patients paroxysmal AF Methods analyzed data from the Apnea Atrial Fibrillation Biomarkers Electrophysiologic Triggers (SAFEBEAT) study designed to examine apnea involving simultaneous collection continuous electrocardiogram monitoring (Heartrak Telemetry®) actigraphy (Actiwatch GTX) for 7-21 days. Heart rate variability (HRV) measures frequency time domains were used as surrogates function averaged per sleep/wake day. A linear mixed-effects model assuming compound symmetry correlation structure was assess relationship HRV actigraphy-derived data. Results The analytic sample (age 60.1±12 years, body mass index 32.6±6.7 kg/m², 36% female, 75% White) included 108 participants AF. Significant observed between indices wakefulness: a) latency high-frequency power (HFP), b) total time, wakefulness after onset (WASO) number awakenings low-frequency (LFP), c) efficiency standard deviation normal R-R intervals (SDNN) coefficient variation (CV). During sleep, LFP/HFP ratio (LHR), LHR. sleep-wake interactions HFP, SDNN CV, WASO SDNN, LFP, d) CV LFP. Conclusion Our novel findings indicate actigraphy-based alterations these relationships exhibited diurnal provide unique insights into differential immediate (during sleep) versus sustained wakefulness) related which may contribute arrhythmogenesis Support (if any)